Tumor and Lymph Node on Chip for cancer studies

[Horizon 2020 project]


Tumor-LN-oC proposes the development and validation of a TRL 5 tumor-lymph node-on-chip (Tumor-LN-oC) platform composed of 3D tissue models and microfluidic chips which will connect surgically removed human primary tumors and LN tissue from the same lung cancer patient. This will serve as a “biological twin” of the patient and will allow us to study the interaction of primary tumors with LNs for individual patients. 

Using sensitive off-chip proteomic and molecular approaches to subsequently analyze the soluble factors present between LN and the tumor the chip will enable characterization of the soluble signals that neutralize the immune response and allow tumor cells to metastasize to the LNs and to use them as spring boards for further dissemination. This will enable the use of existing drugs, or the development of new ones that could reverse this process and inhibit tumor growth and dissemination. It will also allow the identification of novel biomarkers characterizing metastatic cells which could also be exploited therapeutically. 

Moreover, by employing novel imaging approaches, Tumor-LN-oC will generate a spectral “fingerprint” of migrating/metastasizing cells which could be used for diagnostic purposes in tumor and lymph node biopsies.  

More information can be found in the Press Release.